Use of Anti-Hypertension Drug Safety (Labetalol and Nifedipine) During Pregnancy

Abstract

Efforts to manage hypertension in pregnancy, on evidence based medicine using pharmacological therapy lower blood pressure, so it can reduce morbidity and mortality in the maternal and prinatal. Therefore, prior to administration of anti-hypertensive drugs, the need to consider pharmacodynamic and pharmacokinetics that occur in the mother and fetus. Labetalol and nifedipine are category C (FDA) antihypertensive drugs that can be used as an option in the treatment of hypertension during pregnancy, because they do not have teratogenic risks for both pregnant women and the fetus. The making of this article is intended to determine the safety of the use of antihypertensive drugs, labetalol and nifedipine during pregnancy.